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SosokMyeongTang(SMT) have been used in oriental medicine for many centuries as a therapeutic agent for cerebral disease. The effects of SMT on the vascular system is not known. The purpose of this study was to investigate the effects of SMT on the changes in blood pressure(BP) and regional cerebral blood flow(rCBF) of rats. SMT consists of the following components : Radix Ledebouriellae(ÛÁù¦), Radix Cocculi or Stephaniae(ÛÁÐù), Semen Armeniacae(úºìÒ), Cortex Cinnamomi(ë¿Ìý), Radix Scutellariae(üÜÐÙ), Radix Paeoniae Lactiflorae(ÛÜíËå·), Radix Ginseng(ìÑ߸), Rhizoma Cnidll(ô¹Ïä), Herba Ephedrae(Ø«üÜ), Radix Glycyrrhizae(Êöõ®), Radix Aconiti(ݾí?), Fructus Zizyphi Jujubae(ÓÞðÊ), Rhizoma Zingiberis(ßæ˹) and the changes of BP and rCBF were tested Leser-Doppler Flowmetry(LDF) The experimental results were as follows ; BP was not affected by SMT in rats, but rCBF was increased significantly by SMT in a dose dependent manner. SMT increased previous decreasd rCBF due to pretreatment methylene blue, but did not increased previous decreasd rCBF due to pretreatment L-NNA, indomethacin. Pretreatment with indomethacin decreased BP compaired with control group. These results suggest that SMT causes a diverse response of blood pressure and regional cerebral blood flow(rCBF). The increased rCBF is mediated by nitric oxide synthease.
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